Which therapy is primarily preventive, requiring injections at regular intervals?

Prepare for the Pharmacology IV – Headache Therapeutics Test. Review the therapeutic approaches, tackle multiple-choice questions with explanations, and boost your test-taking confidence. Ace your exam with precision!

Multiple Choice

Which therapy is primarily preventive, requiring injections at regular intervals?

The key idea is preventive migraine therapy delivered by long-acting injections. CGRP monoclonal antibodies are designed specifically for prevention: they target and block CGRP signaling to reduce how often migraine attacks occur. These biologics are given by injections on a regular schedule (monthly or at longer intervals depending on the agent), making them the classic injectable preventive option. Gepants and lasmiditan are primarily used for acute treatment—gepants are oral CGRP receptor antagonists taken to treat an ongoing attack, not injections for prevention, and lasmiditan is an oral 5-HT1F agonist used for acute relief. Triptans are also acute therapies used to abort a current migraine.

The key idea is preventive migraine therapy delivered by long-acting injections. CGRP monoclonal antibodies are designed specifically for prevention: they target and block CGRP signaling to reduce how often migraine attacks occur. These biologics are given by injections on a regular schedule (monthly or at longer intervals depending on the agent), making them the classic injectable preventive option.

Gepants and lasmiditan are primarily used for acute treatment—gepants are oral CGRP receptor antagonists taken to treat an ongoing attack, not injections for prevention, and lasmiditan is an oral 5-HT1F agonist used for acute relief. Triptans are also acute therapies used to abort a current migraine.

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