Which of the following is an adverse effect particularly noted with CGRP antagonists in nasal spray form?

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Multiple Choice

Which of the following is an adverse effect particularly noted with CGRP antagonists in nasal spray form?

Taste disturbances occur with nasal spray CGRP antagonists because the medication is delivered directly to the nasal mucosa, and some of it can drain into the oropharynx. This exposure can interact with taste receptors, producing dysgeusia (a bitter or metallic taste). This route-specific side effect is a hallmark of the nasal formulation. Severe hypertension is not a typical issue with gepants, as these drugs don’t primarily cause vasoconstriction. Hemolytic anemia is not associated with this drug class, and visual disturbances are not a common or characteristic adverse effect of nasal CGRP antagonists.

Taste disturbances occur with nasal spray CGRP antagonists because the medication is delivered directly to the nasal mucosa, and some of it can drain into the oropharynx. This exposure can interact with taste receptors, producing dysgeusia (a bitter or metallic taste). This route-specific side effect is a hallmark of the nasal formulation.

Severe hypertension is not a typical issue with gepants, as these drugs don’t primarily cause vasoconstriction. Hemolytic anemia is not associated with this drug class, and visual disturbances are not a common or characteristic adverse effect of nasal CGRP antagonists.

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