Which of the following is a common adverse drug reaction associated with NSAIDs?

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Multiple Choice

Which of the following is a common adverse drug reaction associated with NSAIDs?

The main concept here is that NSAIDs frequently irritate the stomach lining. They block cyclooxygenase enzymes, which reduces prostaglandins that normally protect the gastric mucosa by promoting mucus and bicarbonate production, maintaining blood flow, and supporting the mucosal barrier. With fewer protective prostaglandins, the gastric lining becomes more susceptible to irritation and injury, leading to dyspepsia and abdominal pain. This GI upset is by far the most common adverse effect seen with NSAIDs and is dose- and duration-dependent, and it’s more likely in older patients or with concurrent risk factors. Hepatotoxicity from NSAIDs is uncommon, weight gain isn’t a typical direct effect (may reflect fluid retention in some settings but not common across NSAIDs), and hyperglycemia is not a characteristic adverse effect of NSAIDs. Therefore, dyspepsia and abdominal pain best represent the common GI-related adverse reaction you would expect with NSAID use.

The main concept here is that NSAIDs frequently irritate the stomach lining. They block cyclooxygenase enzymes, which reduces prostaglandins that normally protect the gastric mucosa by promoting mucus and bicarbonate production, maintaining blood flow, and supporting the mucosal barrier. With fewer protective prostaglandins, the gastric lining becomes more susceptible to irritation and injury, leading to dyspepsia and abdominal pain. This GI upset is by far the most common adverse effect seen with NSAIDs and is dose- and duration-dependent, and it’s more likely in older patients or with concurrent risk factors.

Hepatotoxicity from NSAIDs is uncommon, weight gain isn’t a typical direct effect (may reflect fluid retention in some settings but not common across NSAIDs), and hyperglycemia is not a characteristic adverse effect of NSAIDs. Therefore, dyspepsia and abdominal pain best represent the common GI-related adverse reaction you would expect with NSAID use.

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