Which monoclonal antibody is used for migraine prophylaxis?

Prepare for the Pharmacology IV – Headache Therapeutics Test. Review the therapeutic approaches, tackle multiple-choice questions with explanations, and boost your test-taking confidence. Ace your exam with precision!

Multiple Choice

Which monoclonal antibody is used for migraine prophylaxis?

Monoclonal antibodies for migraine prevention work by directly neutralizing CGRP signaling, a key driver of migraine pathophysiology. Fremanezumab binds the CGRP peptide itself, preventing it from activating its receptor. With CGRP activity reduced, the frequency of migraine days tends to decrease in both episodic and chronic migraine. It’s given as a subcutaneous injection, typically on a monthly or quarterly schedule, depending on the dosing plan. This mechanism is different from small-molecule CGRP receptor antagonists like rimegepant, which block the CGRP receptor rather than removing the ligand. It also differs from topiramate, a broad-acting CNS drug, and candasartan, an antihypertensive with no standard migraine preventive use. So, fremanezumab is the monoclonal antibody used for migraine prophylaxis.

Monoclonal antibodies for migraine prevention work by directly neutralizing CGRP signaling, a key driver of migraine pathophysiology. Fremanezumab binds the CGRP peptide itself, preventing it from activating its receptor. With CGRP activity reduced, the frequency of migraine days tends to decrease in both episodic and chronic migraine. It’s given as a subcutaneous injection, typically on a monthly or quarterly schedule, depending on the dosing plan. This mechanism is different from small-molecule CGRP receptor antagonists like rimegepant, which block the CGRP receptor rather than removing the ligand. It also differs from topiramate, a broad-acting CNS drug, and candasartan, an antihypertensive with no standard migraine preventive use. So, fremanezumab is the monoclonal antibody used for migraine prophylaxis.

More practice questions