Which agents are gepants used for migraine management?

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Multiple Choice

Which agents are gepants used for migraine management?

Gepants are small-molecule blockers of the CGRP receptor, used to treat migraine by preventing CGRP from promoting migraine pain and vasodilation. They are distinct from triptans (which are serotonin receptor agonists used for acute treatment) and from CGRP-targeting monoclonal antibodies (used mainly for prevention). The two agents that fit this class are rimegepant and atogepant. Rimegepant is approved for acute treatment and also has preventive use in some settings, while atogepant is approved for preventive therapy of episodic migraine. Erenumab and galcanezumab are monoclonal antibodies targeting CGRP or its receptor, not gepants. Sumatriptan is a triptan, not a gepant.

Gepants are small-molecule blockers of the CGRP receptor, used to treat migraine by preventing CGRP from promoting migraine pain and vasodilation. They are distinct from triptans (which are serotonin receptor agonists used for acute treatment) and from CGRP-targeting monoclonal antibodies (used mainly for prevention).

The two agents that fit this class are rimegepant and atogepant. Rimegepant is approved for acute treatment and also has preventive use in some settings, while atogepant is approved for preventive therapy of episodic migraine. Erenumab and galcanezumab are monoclonal antibodies targeting CGRP or its receptor, not gepants. Sumatriptan is a triptan, not a gepant.

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