What are the common injection-site reactions for CGRP monoclonal antibodies?

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Multiple Choice

What are the common injection-site reactions for CGRP monoclonal antibodies?

Injection-site reactions are common with subcutaneously given CGRP monoclonal antibodies because the body’s local tissue responds to the injected protein. The most frequent local signs at the injection site are redness (erythema), swelling (edema), and itching (pruritus). These reflect mild local inflammation and are usually brief. Systemic symptoms like nausea/vomiting, hair loss, or cough and shortness of breath are not typical injection-site reactions, since they involve broader body systems rather than the injection area. If reactions are bothersome, rotating injection sites and applying a cool compress can help, and persistent symptoms should be discussed with a clinician.

Injection-site reactions are common with subcutaneously given CGRP monoclonal antibodies because the body’s local tissue responds to the injected protein. The most frequent local signs at the injection site are redness (erythema), swelling (edema), and itching (pruritus). These reflect mild local inflammation and are usually brief. Systemic symptoms like nausea/vomiting, hair loss, or cough and shortness of breath are not typical injection-site reactions, since they involve broader body systems rather than the injection area. If reactions are bothersome, rotating injection sites and applying a cool compress can help, and persistent symptoms should be discussed with a clinician.

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