In acute migraine therapy, NSAIDs provide analgesia and anti-inflammatory effects and are often used with triptans; chronic overuse should be avoided due to GI/renal risk.

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NSAIDs in acute migraine therapy provide analgesia and anti-inflammatory effects and are commonly used with triptans. They help relieve pain quickly by reducing the inflammatory mediators that sensitize trigeminal pain pathways. When used with triptans, which work by constricting cerebral vessels and inhibiting CGRP release, the combination targets both peripheral inflammation and central neurovascular processes, leading to more effective and often faster relief than either agent alone. However, chronic overuse should be avoided because of gastrointestinal and renal risks, and to prevent medication-overuse headaches. NSAIDs are not curative for migraine and are primarily for acute treatment, with prophylaxis reserved for preventing frequent attacks.