For chronic migraine, which dosing option reflects onabotulinumtoxin A administration?

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Multiple Choice

For chronic migraine, which dosing option reflects onabotulinumtoxin A administration?

The key concept is that chronic migraine prevention with onabotulinumtoxinA uses a fixed-dose, multi-site intramuscular regimen. The approved approach delivers a total of 155 units per session across 31 injection sites spread through seven head and neck muscle regions, with about 5 units injected at each site. This distribution targets multiple muscles implicated in migraine and provides even coverage rather than bolusing a single area. That is why the option describing about 5 units injected and distributed across the seven head/neck muscles best fits the standard PREEMPT protocol. The other choices don’t mirror this multi-site, intra-muscular dosing pattern (and one option even suggests an IV route, which is not how it’s given).

The key concept is that chronic migraine prevention with onabotulinumtoxinA uses a fixed-dose, multi-site intramuscular regimen. The approved approach delivers a total of 155 units per session across 31 injection sites spread through seven head and neck muscle regions, with about 5 units injected at each site. This distribution targets multiple muscles implicated in migraine and provides even coverage rather than bolusing a single area. That is why the option describing about 5 units injected and distributed across the seven head/neck muscles best fits the standard PREEMPT protocol. The other choices don’t mirror this multi-site, intra-muscular dosing pattern (and one option even suggests an IV route, which is not how it’s given).

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