Basilar migraine has a relative contraindication to the use of which class of drugs?

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Multiple Choice

Basilar migraine has a relative contraindication to the use of which class of drugs?

Triptans are 5-HT1B/1D receptor agonists that cause constriction of intracranial vessels and inhibit release of pain-signaling peptides, effectively treating acute migraine. In basilar migraine, symptoms reflect involvement of the brainstem and posterior circulation. The vasoconstrictive effect of triptans can potentially reduce blood flow in the vertebrobasilar system, raising the risk of brainstem ischemia. Because of this concern, triptans are considered a relative contraindication in basilar migraine. For context, ischemic heart disease is a known absolute contraindication due to the risk of coronary vasospasm; controlled hypertension is not a contraindication when well managed; and migraine with aura is not a contraindication to triptans.

Triptans are 5-HT1B/1D receptor agonists that cause constriction of intracranial vessels and inhibit release of pain-signaling peptides, effectively treating acute migraine. In basilar migraine, symptoms reflect involvement of the brainstem and posterior circulation. The vasoconstrictive effect of triptans can potentially reduce blood flow in the vertebrobasilar system, raising the risk of brainstem ischemia. Because of this concern, triptans are considered a relative contraindication in basilar migraine.

For context, ischemic heart disease is a known absolute contraindication due to the risk of coronary vasospasm; controlled hypertension is not a contraindication when well managed; and migraine with aura is not a contraindication to triptans.

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